|   | ||||
|  | 1940 |  | ||
|  | 1940 |  | ||
| G. W. Beadle and E. L. Tatum publish their classic study on the 
       biochemical genetics of Neurospora and promulgate the ONE-GENE, ONE-ENZYME theory. 
                  K. Mather coins the term polygenes and describes polygenic traits in various organisms.
       | 1941 |  | ||
| S. E. Luria and T. F. Anderson publish the first electron micrographs 
                 of bacterial viruses. T2 has a polyhedral body and a tail. | 1942 |  | ||
| S. E. Luria and M. Delbrück initiate the field of bacterial genetics 
       when they demonstrate unambiguously that bacteria undergo spontaneous mutation. | 1943 |  | ||
| O. T. Avery, C. M. MacLeod, and M. McCarty describe the pneumococcus 
                 transforming principle. The fact that it is rich in DNA suggests that DNA and 
                 not protein is the hereditary chemical. | 1944 |  | ||
| S. E. Luria demonstrates that mutations occur in bacterial viruses. | 1945 | FDR dies in office. 
       
       Harry S. Truman becomes thirty-third president of the United States.       
       | ||
| J. Lederberg and E. L. Tatum demonstrate genetic recombination in bacteria. Genetic recombination in bacteriophage is demonstrated by M. Delbrück and W. T. Bailey and by A. D. Hershey. Nobel Prize in Medicine awarded to H. J. Muller for his contributions to radiation genetics | 1946 |  | ||
|  | 1947 |  | ||
| H. J. Muller coins the term dosage compensation. 
                 J. Lederberg and N. Zinder, and, independently, B. D. Davis develop 
                 the penicillin selection technique for isolating biochemically deficient bacterial mutants.
       | 1948 |  | ||
| A. D. Hershey and R. Rotman demonstrate that genetic recombination occurs in bacteriophage. 
       J. V. Neel provides genetic evidence that the sickle-cell disease is inherited as a simple 
                 Mendelian autosomal recessive.
       | 1949 |  | ||
|  | 1950 |  | ||
|   |